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Activated by the antibiotic rifampicin and different plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to particular ligands is species-precise. Activated by Normally taking place steroids, like pregnenolone and progesterone. Binds to some reaction ingredient while in the promoters on the CYP3A4 and ABCB1/MDR1